Pulmonary biosynthesis and metabolism of prostaglandins and related substances.

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Pulmonary biosynthesis and metabolism of prostaglandins and related substances.

On passage through the lung vascular bed, prostaglandins are removed from the circulation by a transport carrier and subsequently inactivated by intracellular enzymes. However, PGI2 is not inactivated by the lung in vivo. Although PGI2 is an excellent substrate for the intracellular enzymes in vitro, PGI2 is not a substrate for the carrier system. Thus, the transport carrier determines which ci...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1984

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.8455159